Valacyclovir-Induced Neurotoxicity in a Maintenance Hemodialysis Patient

J. Hwang, Hyojeong Song, H. Jo, Song I Lee, B. Lim, Jung-Sub Song, S. Ahn
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Abstract

Valacyclovir is an oral antiviral agent used in the treatment of herpesvirus infection. Although neuropsychiatric symptoms may accompany the use of this drug, valacyclovir is increasingly used to treat herpes zoster, as it is more effective when orally administered. This paper reports one case of neurotoxicity of valacyclovir in patients with end stage renal disease who were undergoing maintenance hemodialysis. Valacyclovir can induce life-threatening neurotoxicity, especially in end stage renal disease patients despite the appropriate dose reduction. Furthermore, Valacyclovir-induced neurotoxicity can be effectively managed by intensive hemodialysis.
维持性血液透析患者缬环韦诱导的神经毒性
Valacyclovir是一种用于治疗疱疹病毒感染的口服抗病毒药物。尽管使用这种药物可能伴随神经精神症状,但伐昔洛韦越来越多地用于治疗带状疱疹,因为口服给药更有效。本文报道一例维持性血液透析终末期肾病患者服用伐昔洛韦的神经毒性。伐昔洛韦可引起危及生命的神经毒性,特别是在终末期肾脏疾病患者,尽管适当的剂量减少。此外,伐昔洛韦引起的神经毒性可以通过强化血液透析有效地管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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