Simultaneous study of the biodistribution of radio-yttrium complexed with EDTMP and citrate ligands in tumour-bearing rats

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology Pub Date : 1992-02-01 DOI:10.1016/0883-2897(92)90008-M

G.J. Beyer, R. Bergmann, G. Kampf, P. Mäding, F. Rösch

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引用次数: 16

Abstract

The influence of the ligands ethylenediaminetetramethylene phosphonic acid (EDTMP) and citrate (CIT) on the biodistribution of radio-yttrium in rats bearing a DS-carcinosarcoma was compared. ⁸⁸Y-EDTMP and ⁸⁷Y-CIT were i.v. injected into the same animals. Faster blood clearance and higher renal excretion were observed for the EDTMP-ligand. Of high practical interest is the reduced liver uptake of radio-yttrium (by one order of magnitude) with the EDTMP complex. Since bone and tumour accumulation is only weakly influenced, high tumour-to-liver ratios (up to 14) were observed. We propose to use EDTMP or similar complex ligands for liver blocking when radionuclides like ⁹⁰Y, ¹⁶⁹Yb, ²²⁵Ac or other group 3 elements are to be applied in endoradionuclide therapy technique.

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放射性钇与EDTMP和柠檬酸盐配体在荷瘤大鼠体内生物分布的同时研究

比较了配体乙二胺四亚甲基膦酸(EDTMP)和柠檬酸(CIT)对ds -癌肉瘤大鼠体内放射性钇生物分布的影响。将88Y-EDTMP和87Y-CIT静脉注射到同一动物体内。edtmp配体的血液清除率更快，肾脏排泄量更高。具有高度实际意义的是EDTMP复合物降低肝脏对放射性钇的摄取(降低一个数量级)。由于骨和肿瘤积聚仅受微弱影响，因此观察到较高的肿瘤与肝脏比率(高达14)。当放射性核素如90Y、169Yb、225Ac或其他3族元素应用于内源性核素治疗技术时，我们建议使用EDTMP或类似的复合配体进行肝脏阻断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

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