Autologous matrix-induced chondrogenesis (AMIC)

Abstract

ABSTRACT Objective: To analyze the evolution and current status of the autologous matrix-induced chondrogenesis (AMIC) technique and know its underlying biological principles, as well as the results of its use in treating chondral lesions. Method: A literature review is made of the basic science referred to cartilage injuries, the surgical technique, and clinical outcomes versus other chondral repair and regeneration techniques. Results: According to the published studies, AMIC improves pain and the clinical and functional scores, affording better outcomes than microfracture surgery and with results similar to those of other repair techniques. Conclusions: Matrix-induced chondrogenesis is a safe, technically reproducible and effective technique for the treatment of cartilage injuries, with good clinical outcomes for the patients. However, long-term studies are needed to assess the evolution of the results over time. Level of evidence: 5. Clinical relevance: It is important to know one of the options available for the treatment of chondral lesions. Within the range of existing treatments, AMIC is a relatively novel technique affording promising results.