Commentary: Comparative Genomic Analysis of Ten Clinical Streptococcus pneumoniae Collected From a Malaysian Hospital Reveal 31 New Unique Drug-Resistant SNPs Using Whole Genome Sequencing

Abstract

Despite the effort and decades of research, S. pneumoniae remains a primary cause of infectious morbidity and mortality worldwide. Although Antibiotics are lifesaving medications that offer tremendous benefits to patients with infectious diseases. Yet, several reports have revealed that the overuse and misuse of these agents had led to antibiotic resistance. Our study utilized whole genome sequencing (WGS) to reveal the pattern of antibiotic-resistance among ten pneumococcal isolates with various degree of susceptibility to antibacterial drugs. The main purpose of our study was to explore genetic variations related to drug-resistance in those ten strains. The results indicated that pneumococcal strains with resistant profile were associated with greater number of SNPs compared to susceptible ones. Out of all the SNPs identified, 31 were unique and had not been reported before. Our data propose that these SNPs could possess an important role in modifying the degree of sensitivity to different antibacterial drugs. In this article we comment on the methodology and results of our study which previously published in Journal of Biomedical Science.