Is Genomic Selection Viable for Dairy Goats in Developing Countries?

R. Lôbo
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Abstract

The linkage disequilibrium (DL) measures the degree of association between alleles on the same chromosomes or on different chromosomes. If there are higher frequencies in these associations, it is indicated that these genes are linked and some serve as markers for others. In this way, it is possible to make selection of genes of economic importance based on the frequency of others that are linked to them. LD forms mainly in the evolutionary process of and animal population selection. Studies showed that dairy goat population in many parts of the world have low DL. Thus, the selection process in these populations was not of intensity to promote high LD. We can stress that selection by molecular markers would produce inefficient results in these population, especially in developing countries with informal dairy goats’ market, and the high cost for animal genotyping would not be justified at this time. Abbreviations: GS: Genomic Selection; LD: Linkage Disequilibrium; QTL: Quantitative Trait Loci; SNP: Single Nucleotide Polymorphisms; GEBV: Genomic Breeding Values; MAF: Minor Allele Frequency
基因组选择在发展中国家是否可行?
连锁不平衡(DL)衡量的是同一染色体或不同染色体上等位基因之间的关联程度。如果这些关联的频率较高,则表明这些基因是有联系的,有些基因可以作为其他基因的标记。这样,就有可能根据与其相关的其他基因的出现频率来选择具有经济重要性的基因。遗传变异主要在动植物种群选择的进化过程中形成。研究表明,世界上许多地方的奶山羊的DL值都很低。因此,在这些种群中,选择过程的强度不足以促进高LD。我们可以强调的是,在这些种群中,通过分子标记进行选择将产生低效的结果,特别是在拥有非正规奶山羊市场的发展中国家,此时进行动物基因分型的高成本是不合理的。GS:基因组选择;LD:连杆不平衡;QTL:数量性状位点;SNP:单核苷酸多态性;GEBV:基因组育种价值;MAF:小等位基因频率
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