Gold coated cobalt nanoparticles as SAR controlling agent for hyperthermia applications

Abstract

In the present paper, we make an attempt to understand the effect of magnetic nanoparticle in the presence of low power RF exposure for hyperthermia application. In light of that, we have considered cobalt nanoparticle (CoNP), and gold coated cobalt nanoparticles (AuCoNP) dispersed in two different media ethanol and water to study RF exposure. Measurement in two different dispersive medium for nano particles is carried out only to understand the actual effect of CoNP and AuCoNP. The proposed measurements being carried out on CoNP and AuCoNP dispersed in tissue equivalent liquid prepared as per IEEE-1528, 2013. Both nanoparticles are used as a controlling agent for Electric (E)- field distribution and E-field intensity hence they can also be used as Specific absorption rate (SAR) controlling agents. The study used a reliable and standardized microwave field exposure system to achieve better temperature control using low-level exposure power (at high frequency, i.e., 2.45GHz). The minimum requirements of in vitro studies have been proposed, analyzed and designed. The developed exposure setup uses a Gigahertz Transverse Electromagnetic (GTEM) cell resonant at 2.45GHz. The tissue equivalent liquids with 5nm sized CoNP and AuCoNP nanoparticles are exposed in 50mm glass beakers. The E- field distribution is calculated at varied microwave power for both particles.