Stoffwechselprodukte von mikroorganismen 201. Mitteilung: Ansatrienin A und B, fungistatische antibiotika aus Streptomyces collinus

Zentralblatt für Bakteriologie Mikrobiologie und Hygiene: I. Abt. Originale C: Allgemeine, angewandte und ?kologische Mikrobiologie Pub Date : 1981-08-01 DOI:10.1016/S0721-9571(81)80035-X

Wolfgang Weber , Hans Zähner , Manfred Damberg , Peter Russ , Axel Zeeck

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引用次数: 4

Abstract

Streptomyces collinus ssp. collinus (Lindenbein) strain Tü 1892 produces ansatrienin A and B which show antifungal activity. Bacteria are not or only weakly inhibited. From a chemical point of view ansatrienins are members of the ansamycin antibiotics. They have a 1,4-benzoquinone resp. hydroquinone nucleus, and moreover an ansa bridge consisting of 18 links which shows an isolated triene part. The colourless ansatrienin B is oxidized into the yellow ansatrienin A with the molecular formula C₃₆H₄₈N₂O₈. The ansatrienins contain a N-cyclohexylcarbonyl-alanine side chain which is linked to the ansa bridge like an ester.

The structure elements of the ansatrienins are related to the maytansinoids.

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病原体201说明:"旁通A和B

猪链霉菌collinus (Lindenbein)菌株Tü 1892产生抗真菌活性的ansatrienin A和B。细菌没有或只有微弱的抑制作用。从化学角度看，安霉素是安霉素类抗生素的成员。它们有1,4-苯醌类。对苯二酚核，此外还有一个由18个键组成的环桥，其中有一个孤立的三烯部分。无色的血清素B被氧化成黄色的血清素A，分子式为C36H48N2O8。ansaenins含有一个n -环己基羰基丙氨酸侧链，它像酯一样连接在ansa桥上。房颤素的结构元素与美黄素类有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zentralblatt für Bakteriologie Mikrobiologie und Hygiene: I. Abt. Originale C: Allgemeine, angewandte und ?kologische Mikrobiologie

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