HMNPPID: A Database of Protein-protein Interactions Associated with Human Malignant Neoplasms

Abstract

Protein-protein interactions (PPIs) play a key role in varies aspects of the structural and functional organization of the cell. Knowledge about them unveils the molecular mechanisms of biological processes. At the same time, the PPIs related to human malignant neoplasms can shed light on the biology behind these neoplasms. However, there is no such PPI database available so far. We constructed a database of protein-protein interactions associated with human malignant neoplasms, named HMNPPID, which contains the PPIs of 171 kinds of human malignant neoplasms. HMNPPID provides healthcare professionals with the PPIs of specific malignant neoplasm without digging into amounts of biomedical literatures, which significantly improves the efficiency of researches on the PPIs of malignant neoplasms. In addition, a visualization program, VisualPPI, is provided to facilitate the analysis of the specific PPI network for a malignant neoplasm.