A comparative study on CRP and ESR in the diagnosis of pediatric septicemia: An institutional experience

Abstract

Introduction: Sepsis is a life-threatening condition that occurs when the body's response to an infection damages its own tissues and organs. In children, sepsis is a leading cause of death. This study aimed to compare the diagnostic efficacy of C-Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR) in pediatric patients with suspected septicemia. Material and Methods: This retrospective study included 125 pediatric patients aged 0-12 years, comprising a sepsis group (n=75) and a control group (n=50). Demographic data, presenting symptoms, vital signs on presentation, and laboratory results, including CRP and ESR levels, were recorded and analyzed. Results: Mean CRP levels were significantly higher in the sepsis group than in the control group. Similarly, mean ESR was higher in the sepsis group. Both parameters correlated with the severity of symptoms and aberrant vital signs on presentation. Conclusion: Both CRP and ESR showed significant elevation in pediatric septicemia, with CRP appearing more accurate and reliable. Further large-scale, prospective studies are needed to validate these findings and establish standardized cut-off levels for these biomarkers in diagnosing pediatric sepsis.