Nanoencapsulation of Zerumbone in Oleic Acid-Modified Chitosan Nanoparticles

E. R. Wikantyasning, S. D. Andasari, M. Da'i, Asyafra Nabila
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引用次数: 1

Abstract

Zerumbone is an active compound of Zingiber zerumbet which has been shown to possess antioxidant and anticancer activities. The limited therapeutic application of this compound was due to its poor water solubility. The aim of this study was to encapsulate zerumbone in hydrophobic chitosan nanoparticles that modified using oleic acid. Oleic acid-modified chitosan was synthesized by coupling chitosan with oleic acid through the 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide HCl-mediated reaction, and was characterized using Fourier-transform infrared (FTIR) spectroscopy. Isolated zerumbone was coated by oleic acid-modified chitosan using ionic-gelation method. The nanoparticles was characterized using particle size analyzer for particle size and zeta potential, and the entrapment efficiency was determined by measuring the concentration of zerumbone using gas chromatography-mass spectroscopy. It was found that prepared zerumbone loaded-nanoparticles had an average size in the range from 500 to 580 nm and carried a positive charge with the zeta potential in the range of +16 to +30 mV. The entrapment efficiency of nanoparticles was about 6 times higher than encapsulation efficiency of zerumbone in chitosan nanoparticles. The nanoparticles have great potential for delivery of zerumbone as anticancer.
油酸修饰壳聚糖纳米颗粒中Zerumbone的纳米包封
Zerumbone是生姜中的一种活性化合物,已被证明具有抗氧化和抗癌活性。这种化合物的有限的治疗应用是由于其水溶性差。本研究的目的是将零骨包埋在疏水壳聚糖纳米颗粒中,壳聚糖纳米颗粒经油酸修饰。以1-乙基-3-(3-二甲氨基丙基)碳二酰亚胺为介质,将壳聚糖与油酸偶联,合成了油酸改性壳聚糖,并用傅里叶红外光谱对壳聚糖进行了表征。采用离子凝胶法制备油酸修饰壳聚糖包被分离的零骨。采用粒径分析仪测定纳米颗粒的粒径和zeta电位,采用气相色谱-质谱联用技术测定纳米颗粒的包封效率。结果表明,所制备的零骨负载纳米粒子的平均粒径在500 ~ 580 nm之间,带正电荷,zeta电位在+16 ~ +30 mV之间。壳聚糖纳米颗粒的包封效率是零元骨包封效率的6倍左右。纳米颗粒作为抗癌药物,具有很大的输送潜能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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