Spontaneous Activity and Evoked response change to 100ms temporal stimulation in Dissociated Neuronal Networks

Abstract

Temporal learning is one of the most basic ability within human brain, which enables people to perform complex tasks as playing and skilled works. However, the mechanism is not well understood. Recent studies have shown that neurons in whole cell recording in brain slices have ability to remember given time interval stimulation. However, the mechanism behind temporal memory and how the learned pattern changes performance within network spontaneous activity remains unknown. To understand the effect of temporal learning in network activity, our team uses in vitro models present as the simplest neuronal network for studying properties of network dynamics, and show how activity changes to learned stimulation in neuronal networks, which may imply long term learning also possess within cortical cultures.