Indium Tin Oxide Coated Surface Plasmon Resonance Based Biosensor for Cancer Cell Detection

Abstract

This A novel conventional single-core SPR-based cancerous or malignant cell detector sensor is demonstrated for the rapid identification and monitoring of cancer-affected distinct cell types. Each cancer-infected cell's refractive index (RI) is contrasted to the RI of its own healthy individual, and significant variations in optical properties are discovered. Moreover, the concentration of cancerous cells in liquid is estimated at 80%, and the finite element method (FEM) is used for detection (FEM). A thin indium tin oxide (ITO) film coating (50 nm) separates the silica and cancer cell parts, allowing for a plasmonic band gap to vary the spectral shift. The suggested sensor has a significant level of birefringence of 0.035 and a length of the coupling of up to 70 μm, On the other hand, the proposed model gives an ideal wavelength sensitivity level of around 10357.14 nm/RIU and 17750 nm/RIU, with a sensor resolution of 1.41x10−3 RIU and 7.37x10−3 RIU. In addition, the transmittance variance of cancerous cells varies from nearly 4100 dB/RIU to 6800 dB/RIU, in primary polarization mode, the amplitude sensitivities for various cancer cells range from about -405 RIU−1 to -430 RIU−1, with a detection limit of 0.025.