Effect of Curcuma Zedoaria Extract on Testis and Seminal Vesicle Weights in White Rats

Strengthening Hospital Competitiveness to Improve Patient Satisfaction and Better Health Outcomes Pub Date : 2019-10-23 DOI:10.26911/the6thicph-FP.03.03

Rini Anggeriani

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Abstract

Background: The participation of men in family planning, particularly in Indonesia, is still lacking. Men dislike condom and vasectomy. Therefore, experts are trying to find a safe way for men by switching modern contraceptives to plants that can inhibit spermatogenesis. Plant that has an antifertility potential is Curcuma zedoaria (Berg) Rosc. This study aimed to examine the effect of Curcuma zedoaria extract on testis and seminal vesicle weights in white rats (Rattus norvegicus). Subjects and Method: This was a completely randomized design (CRD) study with posttest only group design. A total of 24 male white rats were selected for this study and then randomized into two groups: intervention group and control group. The dependent variable was testis and seminal vesicle weights. The independent variable was Curcuma zedoaria extract. The rats in the intervention group were treated with Curcuma zedoaria extract in a dose of 300 mg/kgBW for 48 days. The data were analyzed by Independent Sample T-test. Results: Testis and seminal vesicle weights were comparable and its mean difference was statistically non-significant indicating the success of randomization. Testis and seminal vesicle weights were lower in the intervention group than in the control group, and it was statistically significant. Conclusion: The administration of Curcuma zedoaria extract can effectively reduce testis and seminal vesicle weights in male white rats.

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莪术提取物对大鼠睾丸和精囊重量的影响

背景:特别是在印度尼西亚，男子对计划生育的参与仍然不足。男人不喜欢避孕套和输精管结扎术。因此，专家们正试图为男性找到一种安全的方法，将现代避孕药换成能够抑制精子发生的植物。具有抗生育潜力的植物是莪术(Curcuma zedoaria)。本研究旨在探讨莪术提取物对褐家鼠睾丸和精囊重量的影响。对象和方法:这是一项完全随机设计(CRD)研究，仅采用后测组设计。本研究选取雄性大鼠24只，随机分为干预组和对照组。因变量为睾丸和精囊重量。自变量为莪术提取物。干预组大鼠以300 mg/kgBW剂量莪术提取物治疗48 d。数据采用独立样本t检验。结果:睾丸和精囊重量具有可比性，其平均差异无统计学意义，表明随机化成功。干预组睾丸、精囊重量均低于对照组，差异有统计学意义。结论:莪术提取物能有效降低雄性大鼠睾丸和精囊重量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Strengthening Hospital Competitiveness to Improve Patient Satisfaction and Better Health Outcomes

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