Photon counting polarimetry measurement towards non-invasive biomedical glucose monitoring

Abstract

Commercially available glucose measurement device for diabetes monitoring require extracting of blood and this means there will be a physical contact with human body. Demand on non-invasive measurement has invites research and development of new detection methods to measure blood glucose level. In this work, a very sensitive optical polarimetry measurement technique using ratio-metric photon counting detection has been introduced and tested for a range of known glucose concentrations that mimic the level of glucose in human blood. The setup utilizes 785nm diode laser that emits weak coherent optical signal onto glucose concentration samples in aqueous. The result shows a linear proportional of different glucose concentration and successfully detected 10260 mg/dl to 260 mg/dl glucose samples. This indicates a potential improvement method for non-invasive glucose measurement by a sensitive polarimetry based optical sensor in single photon level for biomedical applications.