{"title":"Trans-prostaglandin E2 enhances fibrinolysis.","authors":"T Urano, M Shimokawa, T Kinoshita","doi":"10.1248/bpb1978.15.261","DOIUrl":null,"url":null,"abstract":"<p><p>5,6-trans-Prostaglandin E2 (trans-PG E2) was found to accelerate the fibrinolysis in a cell-free system. trans-PG E2 decreased the lysis time by 15% in the fibrin clot lysis time method and increased the lysis area by 22% in the fibrin plate method. On the contrary, 5,6-cis-prostaglandin E2 did not have such effects. trans-PG E2 did not exert the effect in the absence of either tissue-plasminogen activator or plasminogen. These results suggest that trans-PG E2 enhances the generation of plasmin from plasminogen by tissue-plasminogen activator.</p>","PeriodicalId":16743,"journal":{"name":"Journal of pharmacobio-dynamics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1992-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1248/bpb1978.15.261","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pharmacobio-dynamics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1248/bpb1978.15.261","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
5,6-trans-Prostaglandin E2 (trans-PG E2) was found to accelerate the fibrinolysis in a cell-free system. trans-PG E2 decreased the lysis time by 15% in the fibrin clot lysis time method and increased the lysis area by 22% in the fibrin plate method. On the contrary, 5,6-cis-prostaglandin E2 did not have such effects. trans-PG E2 did not exert the effect in the absence of either tissue-plasminogen activator or plasminogen. These results suggest that trans-PG E2 enhances the generation of plasmin from plasminogen by tissue-plasminogen activator.
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