Potential organ or tumor imaging agents. 32. A triglyceride ester of P-Iodophenyl pentadecanoic acid as a potential hepatic imaging agent

International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology Pub Date : 1992-08-01 DOI:10.1016/0883-2897(92)90098-J

S.W. Schwendner , J.P. Weichert , M.A. Longino , M.D. Gross , R.E. Counsell

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引用次数: 1

Abstract

A triglyceride analog, glycerol-2-palmitoyl-1,3-di-15-(p-iodophenyl)pentadecanoate (DPPG) was synthesized and radiolabeled for evaluation as a potential functional liver scintigraphic agent. Uptake of DPPG was compared in normal, diabetic, tumor-bearing and heparin pretreated rats, revealing differences in uptake and clearance of radioactivity, correlating with hepatic lipase activity of these groups. Similar results were observed by γ -camera scintigraphy. Comparing the uptake of DPPG with that of its fatty acid component, 15-(p-iodophenyl)pentadecanoic acid (IPPA), revealed that the peak uptake of IPPA in the liver was about half that of DPPG. Based upon these findings, DPPG warrants further study as a hepatic radiodiagnostic agent.

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潜在的器官或肿瘤显像剂。32. 对碘苯五酸的甘油三酯，作为潜在的肝脏显像剂

合成了甘油三酯类似物甘油-2-棕榈酰-1,3-二-15-(对碘苯基)五酸酯(DPPG)，并对其进行了放射性标记，以评估其作为潜在的功能性肝脏显像剂。比较了正常大鼠、糖尿病大鼠、荷瘤大鼠和肝素预处理大鼠对DPPG的摄取，揭示了这些组在摄取和放射性清除方面的差异，并与肝脂肪酶活性相关。γ -照相机闪烁成像也观察到类似的结果。比较DPPG及其脂肪酸成分15-(对碘苯基)五酸(IPPA)的摄取，发现肝脏对IPPA的摄取峰值约为DPPG的一半。基于这些发现，DPPG作为肝脏放射诊断试剂值得进一步研究。

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International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology

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