Adverse Effects of Bisoprolol in Rats

Advances in Pharmacology & Clinical Trials Pub Date : 1900-01-01 DOI:10.23880/apct-16000164

Alsadek H Bogzil

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Abstract

The present study was designed to investigate the adverse effect of Bisoprolol and protective effect of Vitamin E and To Show the result of the combination between Bisorprolol and Vit. E on hepatic and renal disturbance induced in rats by Bisorprolol. Experimental design: After one week of acclimatization, eighty rats randomly allocated into 4 equal groups, each of 20 rats. The 1st group: Rats in this group were not medicated and left as control and received Nacl as avehicle. The 2nd group (VE): Rats in this group treated with vitamin E (1.8mg/kg b.wt. once daily) per os for Successive 21 days. The 3rd group (B): Rats in this group treated orally with Bisoprolol (1.8mg/kg b.wt. once daily) for successive 21 days as standard. The 4th group (VE+B): Rats in this group received orally a combination of vitamin E (1.8mg/kg b.wt. once daily) with Bisoprolol (1.8mg/kg b.wt. once daily) for Successive 21 day. At the end of the experiment, all rats were sacrificed, Liver and kidney samples were taken and blood was taken to centrifuged to gain serum for biochemical investigations. Effect of Bisoprolol, Vit.E and their combination on liver parameter (ALT, AST, ALP, Total serum proteins, Serum albumin, serum globulin). Oral administration of Bisoprolol (1.8mg/kg b.wt. once daily for 21 days) Showed a significant increase in (ALT, AST, ALP) while total serum proteins, serum albumin, and serum globulin showed a significant decrease compared with control group. Administration of Vit.E (1.8mg/kg b.wt. once daily for 21 days) and its combination with Bisoprolol (1.8mg/kg b.wt. once daily for 21 days) showed a decrease in (ALT, SAT, ALP) while total serum proteins, serum albumin, and serum globulin showed an increased compared with Bisoprolol group. 2Effect of Bisoprolol, Vit.E and their combination on kidney parameters (creatinine and uric acid). Oral administration of bisoprolol (1.8mg/kg b.wt. once daily for 21 days) Showed a significant increase in (Creatinine and uric acid) compared with control group. Administration of Vit E (1.8mg/ kg b.wt. once daily for 21 days and its combination with bisoprolol (1.8mg /kg b.wt. once daily for 21 days) Showed a decrease in (creatinine and uric acid compared with bisoprolol group. 3Effect of Bisoprolol and vit. E on antioxidant activites aCAT, SOD and GPX activity Administration of Bisoprolol (1.8mg/kg b.wt. once daily for 21 days) showed a significant decrease in CAT, SOD and GPX activity compared with control group. Administration of Vit.E (1.8mg/kg b.wt. once daily for 21 days) and its combination with bisoprolol showed a significant increase in CAT, SOD and GPX activity compared with bisoprolol group. bLipid peroxidation (MDA) Oral administration of bisoprolol (1.8mg/kg b.wt. once daily for 21 days) showed a significant increase in MDA activity compared with control group. Research Article

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比索洛尔对大鼠的不良反应

本研究旨在探讨比索洛尔的不良反应和维生素E的保护作用，并展示比索洛尔与维生素E联合使用的效果。E对比索洛尔致大鼠肝肾损害的影响。实验设计:适应1周后，80只大鼠随机分为4组，每组20只。第一组:不给药，留用为对照，以Nacl为载药剂。第二组(VE):给予维生素E (1.8mg/kg b.w.t);每天一次)，连续21天。第三组(B):该组大鼠口服比索洛尔(1.8mg/kg b.wt)。每天一次)，连续21天为标准。第四组(VE+B):该组大鼠口服维生素E (1.8mg/kg b.wt)。比索洛尔(1.8mg/kg b.wt)。每天一次)，连续21天。实验结束时，处死大鼠，取肝肾标本，离心取血，得到血清进行生化检查。比索洛尔的效果。E及其联合作用对肝脏各项指标(ALT、AST、ALP、血清总蛋白、血清白蛋白、血清球蛋白)的影响。口服比索洛尔(1.8mg/kg b.wt)。(1次/ d，连用21 d)血清ALT、AST、ALP显著高于对照组，血清总蛋白、白蛋白、球蛋白显著低于对照组。Vit的管理E(1.8毫克/公斤体重)每日1次，连用21天)，并与比索洛尔(1.8mg/kg b.w.t)合用。与比索洛尔组相比，1次/天，连续21天，ALT、SAT、ALP均下降，血清总蛋白、血清白蛋白、血清球蛋白均升高。比索洛尔的疗效。E及其联合对肾脏参数(肌酐、尿酸)的影响。口服比索洛尔(1.8mg/kg b.wt)。每日1次，连续21天)与对照组相比，肌酐和尿酸显著升高。给药Vit E (1.8mg/ kg b.wt)。每日一次，连用21天，并与比索洛尔(1.8mg /kg b.wt)合用。每日1次，连续21天)与比索洛尔组相比，肌酐和尿酸均下降。比索洛尔与维特的疗效。比洛尔(1.8mg/kg b.wt)对抗氧化活性、aCAT、SOD和GPX活性的影响与对照组相比，CAT、SOD和GPX活性显著降低。Vit的管理E(1.8毫克/公斤体重)每日1次，连用21 d)，与比索洛尔组相比，其与比索洛尔组的CAT、SOD和GPX活性均显著升高。脂质过氧化(MDA)口服比索洛尔(1.8mg/kg b.wt)。1次/ d，连续21 d)， MDA活性显著高于对照组。研究文章

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Advances in Pharmacology & Clinical Trials

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