Role of moonlighting proteins in gut bacteria

Keita Nishiyama
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Abstract

The colonization characteristics of gut bacteria in the intestinal tract are important to understand their potential survival strategies. Bacterial surface adhesion factors are known to be the predominant bacterial molecules involved in host-microbe interaction. Moonlighting refers to the ability of proteins to exert multiple biologically important functions in gut bacteria. The moonlighting proteins have canonical functions in essential cellular processes, such as glycolysis, chaperone activity, and protein synthesis, whereas in their cytoplasmic form, following secretion and localization to the cell surface, they often exert additional functions as an adhesion factor. Here we review the moonlighting protein-mediated colonization process of the gut bacteria, with a focus on the elongation factor Tu (EF-Tu). In addition, we will introduce a new experimental method for evaluating the behavior of moonlighting proteins
兼职蛋白在肠道细菌中的作用
肠道细菌在肠道中的定植特征对于了解其潜在的生存策略非常重要。已知细菌表面粘附因子是参与宿主-微生物相互作用的主要细菌分子。兼职是指蛋白质在肠道细菌中发挥多种重要生物学功能的能力。这些兼职蛋白在基本的细胞过程中具有典型的功能,如糖酵解、伴侣活性和蛋白质合成,而在它们的细胞质形式中,随着分泌和定位到细胞表面,它们通常作为粘附因子发挥额外的功能。在这里,我们回顾了月光蛋白介导的肠道细菌定植过程,重点是延伸因子Tu (EF-Tu)。此外,我们将介绍一种新的实验方法来评估月光蛋白的行为
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