The Role of Circulating Biomarkers in the Early Diagnosis of Ovarian Cancer

Ece Gumusoglu, T. Gunel
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引用次数: 8

Abstract

Ovarian cancer is the leading cause of gynecologic-related cancer death and epithelial ovarian cancer (EOC) is the most lethal sub-type. EOC is usually asymptomatic, and few screening tests are available. Diagnosis of ovarian cancer can be difficult because of the nonspecific symptoms. Despite the various diagnostic methods used, there is no reli able early diagnostic test and it needs to be developed. Specific biomarkers may have potential with the least possible invasive procedure. Biomarkers with a high sensitivity to ovarian cancer should be identified. Circulating biomarkers that are significant tools for non-invasive early diagnosis can be analyzed using circulating tumor cells, exosomes, and circulating nucleic acids. Protein, gene, metabolite, and miRNA-based biomarkers can be used for ovarian cancer diagnosis. As non-coding RNAs, MiRNAs may have an important role in ovarian cancer diagnosis due to their effects on mRNA expression lev - els. The most recent developments regarding the potential of circulating biomarkers to detect early ovarian cancer is presented in this chapter.
循环生物标志物在卵巢癌早期诊断中的作用
卵巢癌是妇科相关癌症死亡的主要原因,上皮性卵巢癌(EOC)是最致命的亚型。EOC通常无症状,很少有筛查试验可用。卵巢癌的诊断可能是困难的,因为非特异性的症状。尽管使用了各种诊断方法,但没有可靠的早期诊断测试,需要开发。特定的生物标记物可能具有最小侵入性手术的潜力。应确定对卵巢癌具有高敏感性的生物标志物。循环生物标志物是非侵入性早期诊断的重要工具,可以使用循环肿瘤细胞、外泌体和循环核酸进行分析。蛋白质、基因、代谢物和基于mirna的生物标志物可用于卵巢癌的诊断。mirna作为一种非编码rna,由于其对mRNA表达水平的影响,可能在卵巢癌诊断中发挥重要作用。本章介绍了循环生物标志物检测早期卵巢癌潜力的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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