A scalable robotic-based laboratory automation system for medium-sized biotechnology laboratories

IEEE International Conference on Automation Science and Engineering, 2005. Pub Date : 2005-09-12 DOI:10.1109/COASE.2005.1506763

Peyman Najmabadi, A. Goldenberg, A. Emili

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引用次数: 8

Abstract

This paper presents a new approach to laboratory automation integration with applications in automatic execution of various biotechnology (genomics and proteomics) protocols. The new configuration is called "tower-based configuration". It provides a scalable workcell that also includes instrumentation for sub-processes such as vortexing, shaking, incubation etc. Tower-based automation is a robotic-based configuration that allows improving the throughput of automated system without changing the robotic workspace or increasing the footprint of the system. Tower configuration consists of two arms mounted on a common cylindrical base, and is surrounded by stackers that carry laboratory processing instruments, labwares and other accessories. The requirement of high throughput is satisfied by parallel processing. A conceptual tower-based automated system for magnetic isolation of TAP tagged protein complexes protocol is presented and compared with a traditional automated system. Our performance investigation showed that the tower-based configuration has a high throughput to footprint ratio, high scalability, and wide protocol flexibility in comparison with traditional laboratory automation approaches.

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一个可扩展的基于机器人的实验室自动化系统，用于中型生物技术实验室

本文提出了一种实验室自动化集成的新方法，应用于各种生物技术(基因组学和蛋白质组学)协议的自动执行。新的配置被称为“基于塔的配置”。它提供了一个可扩展的工作单元，还包括用于子过程的仪器，如漩涡、震动、孵化等。塔式自动化是一种基于机器人的配置，可以在不改变机器人工作空间或增加系统占地面积的情况下提高自动化系统的吞吐量。塔的结构包括安装在一个共同的圆柱形基座上的两个手臂，周围是携带实验室加工仪器、实验室用具和其他配件的堆栈。通过并行处理，满足了高吞吐量的要求。提出了一种基于塔的TAP标记蛋白复合物磁分离自动化系统的概念，并与传统的自动化系统进行了比较。我们的性能调查表明，与传统的实验室自动化方法相比，基于塔的配置具有高吞吐量占用比、高可扩展性和广泛的协议灵活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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IEEE International Conference on Automation Science and Engineering, 2005.

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