Clinical significance of gene polymorphism of xenobiotic detoxification in children with bronchial asthma

Abstract

The phenotypic peculiarities of bronchial asthma (BA) in 94 children from Ivano-Frankivsk region with different types of allelic gene polymorphism of the first phase of xenobiotic detoxification mEPXH1 have been investigated. The association between polymorphism of gene mEPXH1 and susceptibility to occurrence and severity of BA in children have been described. It has been established that the manifestation of asthma as eco-determined pathology is affected by individual types of metabolic activity of genes of xenobiotic detoxification. It has been proved that patients with uncontrolled asthma have genotypes CC and GG (p <0.05) much more often. Children with asthma often have high enzymatic activity of a gene mEPHX1 (polymorphic variants of AG and AA-TT-TT). A “slow” functional state of gene mEPHX1 corresponding to homoand hetero-zygotes for the mutant alleles: СС-АА and ТС-АА is also a frequent phenomenon. It has been established that bronchial asthma as eco-determined pathology is affected by individual variants of metabolic activity of genes of xenobiotic detoxification.