Psidium cattleianum as a possible treatment for oxidative stress caused by SARS-CoV-2 infection

Diana Carolina Carbajal-Lázaro, Andrew Emilio Castillo-Pacheco, Maujuri Jhojany Chigne-Abanto, Ángel Josué Delgado-Ramos, Leonardo Enrique Díaz-Layza, C. P. Escudero-Gaytán, Jorge Ulises Paredes-Landauro, Karla Luz del Rocío Casós-Portocarrero
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Abstract

The SARS-CoV-2 virus presents a lot of proteins in its structure that facilitate host cell infection, generating an increase in the concentration of angiotensin II and activating multiple signaling pathways that stimulate the NADPH oxidase enzyme complex and enzymes that take part in the inflammatory answer. As a consequence, there is an increase in reactive oxygen species (ROS) that damage different proteins, lipids and nucleic acids. Given this, Psidium cattleianumcan capture free radicals or inhibit theformation of ROS by transferring hydrogen atoms and electrons. For that, this research has the main objective to determine the influence of Psidium cattleianumas a possible treatment of oxidative stress caused by the SARS-COV-2 infection in order to consider the consumption of this berry as a possible alternative as an antioxidant treatment.
猪尾金作为SARS-CoV-2感染引起的氧化应激的可能治疗方法
SARS-CoV-2病毒在其结构中呈现出许多促进宿主细胞感染的蛋白质,使血管紧张素II浓度增加,并激活多种信号通路,刺激NADPH氧化酶复合物和参与炎症反应的酶。因此,活性氧(ROS)的增加会损害不同的蛋白质、脂质和核酸。鉴于此,Psidium可以通过转移氢原子和电子来捕获自由基或抑制ROS的形成。为此,本研究的主要目的是确定Psidium cattleanumas对SARS-COV-2感染引起的氧化应激的可能治疗方法的影响,以便考虑食用这种浆果作为一种可能的抗氧化治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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