Study the Effectiveness of Ceftriaxone on Biofilm Formation by Different Strains of E. Coli Isolated from Patients with Urinary Tract Infection.

Abstract

Urinary tract infections are among the most frequent diseases in the world, affecting both males and women around the world. Females are more susceptible to urine tract infections than males, owing to the female body’s anatomical configuration. The pathogenic Escherichia coli is the most common causative agent 80% – 90% of urinary tract infections. This study was carried out in the laboratories of the Medical State University of Grodno. The object of study was taken 4 strains of E. coli from the museum of the Department of Microbiology, Virology and Immunology Medical State University of Grodno where determine the features of the action of Ceftriaxone on various strains of E. coli in the composition of biofilms. The purpose of the study are determination of the effect of Ceftriaxone on biofilm-forming bacteria and select the minimum inhibitory concentration. The results showed that all screened Museum strains of E. coli isolated from pathological material of patients with urinary tract infection are able to form biofilms. The minimum inhibitory concentration of CTX for all studied E. coli biofilms was in the range of 35-280 mg/ml and the minimum inhibitory concentration in plankton was in the range 0.27-0.068 mg/ml.