Extracting ventricular and atrial compliance and mitral impedance from Doppler inflow velocity and chamber pressures: inversion of a mitral flow model

[1989] Proceedings. Computers in Cardiology Pub Date : 1989-09-19 DOI:10.1109/CIC.1989.130467

J.D. Thomas, J. Newell, F. Flachskampf, C. Chen, Chun Ming Liu, A. Weyman

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引用次数: 1

Abstract

A lumped parameter mathematical model of left ventricular filling applicable to analysis of Doppler mitral velocity inflow patterns has been developed. As originally formulated, the model utilizes user-provided chamber compliance and mitral impedance parameters and returns the time course of chamber pressure and mitral velocity and flow. The authors describe their initial experience with an algorithm to invert the model, i.e. to analyze observed pressure and flow data and extract the compliance and impedance parameters underlying the observed curves. This algorithm repeatedly solves the forward model, adjusting the physiologic parameters using the Marquardt method until the fit to the observed pressure and flow data is optimized. This algorithm was tested against computer-generated data with up to 10% Gaussian noise. It has also been validated with data from an in vitro analog of the left heart and from a canine model of mitral stenosis. Other possible inversion schemes, such as those which utilize only noninvasive data, are also discussed.<>

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从多普勒流入速度和室压中提取心室和心房顺应性和二尖瓣阻抗:二尖瓣血流模型的反演

建立了适用于多普勒二尖瓣血流模式分析的左心室充盈集总参数数学模型。正如最初制定的那样，该模型利用用户提供的腔室顺应性和二尖瓣阻抗参数，并返回腔室压力和二尖瓣速度和流量的时间过程。作者描述了他们用一种算法来反演模型的初步经验，即分析观测到的压力和流量数据，并提取观测曲线下的顺应性和阻抗参数。该算法反复求解正演模型，使用Marquardt方法调整生理参数，直到与观测压力和流量数据的拟合最优。该算法针对计算机生成的数据进行了测试，该数据具有高达10%的高斯噪声。它也通过左心体外模拟物和犬二尖瓣狭窄模型的数据得到了验证。其他可能的反演方案，如仅利用非侵入性数据的反演方案，也进行了讨论

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[1989] Proceedings. Computers in Cardiology

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