Effects of chronic intrathecal infusion of BDNF on interneuronal activity in a large animal model of spinal cord injury

Abstract

In the present study, we examined the correlations between the recovery of stepping obtained with intrathecal Brain Derived Neurotrophic Factor (BDNF) delivery via mini-pump to the lumbar spinal cord and the firing of the lumbar spinal interneurons in a feline model of Spinal Cord Injury (SCI).