A phase II study of recombinant interleukin-2 with or without recombinant interferon-beta in non-Hodgkin's lymphoma. A study of the Cancer and Leukemia Group B.

D B Duggan, M T Santarelli, K Zamkoff, S Lichtman, J Ellerton, R Cooper, B Poiesz, J R Anderson, C D Bloomfield, B A Peterson
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引用次数: 23

Abstract

Interleukin-2 (IL-2) and interferon-beta (IFN-beta) have demonstrated activity against lymphoid malignancies, presumably mediated by the augmentation of lymphokine-activated killer (LAK) cell and natural killer (NK) cell activity. There is in vitro and in vivo evidence to suggest that the combination of IL-2 and IFN-beta is synergistic. The Cancer and Leukemia Group B (CALGB) conducted a randomized phase II trial of IL-2 with or without IFN-beta in 49 patients with relapsed or refractory non-Hodgkin's lymphoma (NHL). Overall toxicity was severe, with 17 patients experiencing life-threatening toxicity. Three patients had treatment-related deaths. Responses were noted in seven patients (17%). There were no meaningful differences between treatment arms in toxicity profile, response rate, or modulation of in vivo NK and LAK activity. We conclude that IL-2 with or without IFN-beta is not effective therapy for NHL in the doses and schedule used in this study.
重组白细胞介素-2联合或不联合重组干扰素- β治疗非霍奇金淋巴瘤的II期研究。癌症和白血病B组的研究。
白细胞介素-2 (IL-2)和干扰素- β (ifn - β)已被证明具有抗淋巴细胞恶性肿瘤的活性,可能是由淋巴因子激活的杀伤细胞(LAK)和自然杀伤细胞(NK)活性的增强介导的。有体外和体内证据表明,IL-2和ifn - β联合使用具有协同作用。癌症和白血病B组(CALGB)在49例复发或难治性非霍奇金淋巴瘤(NHL)患者中进行了IL-2联合或不联合ifn - β的随机II期试验。总体毒性很严重,17例患者出现危及生命的毒性。3名患者因治疗而死亡。7例患者(17%)出现缓解。在毒性特征、反应率或体内NK和LAK活性的调节方面,治疗组之间没有显著差异。我们得出结论,在本研究中使用的剂量和方案中,IL-2与ifn - β或不含ifn - β都不是NHL的有效治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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