A Novel Model of Electrical Action Potentials of Teleost Fish Ventricular Myocytes

Hamsa Naser, Dominic G. Whittaker, H. Shiels, M. Boyett, Henggui Zhang
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Abstract

Mathematical modelling, combined with experimental approaches, has become a powerful method for investigating the heart functions. So far, different models of cardiac electrical activities of variant species have been developed. However, models of fish cardiomycytes are less developed. Given the prominent problem of global warming, sea temperature changes will have a significant impact on the development of cardiac arrhythmias in the fish heart, leading to their sudden death, which may impose a heavy burden to the economy of the society. This study aimed to develop a biophysically detailed computer model for the teleost fish ventricular myocytes in warm acclimation (18 °C). A set of Hodgkin-Huxley (HH) formulations have been developed for the major ion currents that were based on experimental data from different teleost species. With a series of supra-threshold stimuli (amplitude of −41 pA/pF; duration of 10 ms and time interval (between two successive stimuli) of 1000 ms) the teleost fish model generates a successful sequence of action potentials (APs). The characteristics of the (APs) matched quantitatively the available experimental findings. In conclusion, a mathematical model for the electrical action potential of the teleost fish cardiac myocytes has been developed and validated.
硬骨鱼心室肌细胞动作电位的新模型
数学建模与实验方法相结合,已成为研究心脏功能的有力方法。到目前为止,已经建立了不同物种心脏电活动的不同模型。然而,鱼类心肌细胞的模型尚不发达。在全球变暖问题突出的情况下,海水温度的变化将对鱼类心脏心律失常的发展产生重大影响,导致鱼类猝死,给社会经济带来沉重负担。本研究旨在建立热驯化(18°C)条件下硬骨鱼心室肌细胞的生物物理详细计算机模型。一套霍奇金-赫胥黎(HH)公式已开发的主要离子电流,是基于实验数据从不同种类的硬骨鱼。具有一系列超阈值刺激(振幅为- 41 pA/pF;持续时间为10 ms,时间间隔(两次连续刺激之间)为1000 ms),硬骨鱼模型产生了一系列成功的动作电位(ap)。(ap)的特性在数量上与现有的实验结果相匹配。综上所述,本文建立了硬骨鱼心肌细胞动作电位的数学模型并进行了验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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