Nucleosome positioning determinants for distinct human genomic features

Abstract

Nucleosome which is the basic chromatin unit plays an important role in the genome packaging. We found the characteristics of nucleosome positioning among different genes of the human CD4 + cells. It was found that a linear combination of approximately 20 factors explaining the nucleosome positioning of each genome. In these linear combinations, a histone modification and the properties of the 6 DNA sequences are shared. Other factors are different. This study has a high resolution, which greatly simplifies the means to predict and understand the different genomic features in human CD4 + cells, providing a more accurate nucleosome occupancy.