Uso de ortobiológicos y aloinjerto en el tratamiento de pseudoartrosis con pérdida ósea diafisaria femoral

Ortho-tips Pub Date : 1900-01-01 DOI:10.35366/103737
Martha Brenda Lobato Saucedo, Rodolfo Sánchez Ayala, Miriam Astrit Barriga Magaña, Juan Antonio Silva Méndez, I. Gutiérrez-Mendoza, Álvaro Rodríguez Barrón, Juan Matus Jiménez, Montserrat García Balletbó, Ramón Cugat Bertomeu
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Abstract

Pseudoarthrosis is a complication that poses a challenge for the orthopedist. If is associated with bone loss, a salvage surgery is indicated. There is no protocol for treatment for pseudoarthrosis with a «critical defect». The induced membrane technique, distraction osteogenesis, among others, has been described; however, the long time and elevated costs involved have opened a new landscape on the research of new protocols. The «diamond concept» which is not only based of improving biomechanics, but also introduces biological stimulation as a pillar of treatment, was recently introduced. We present the case of a 16-year-old female patient with a femoral shaft fracture after a traffic accident, treated initially with a centromedullar blocked nailing that progresses to pseudoarthrosis, presenting a 5 cm bone loss. Treatment consisted of removing the centromedullar blocked nail, resection of the nonviable bone segment, osteosynthesis with another centromedullar blocked nailing, placement a 7 cm diaphyseal allograft, platelet-rich plasma (PRP), matrix allograft, and bone chips, thus achieving radiographic and clinical consolidation; restoring limb function in a shorter time, considering the PRP as the main orthobiological element in this case.
矫形生物学和同种异体移植在股骨髁骨丢失假关节治疗中的应用
假关节是一种并发症,对骨科医生提出了挑战。如果伴有骨质流失,则需要进行手术。有“严重缺陷”的假关节没有治疗方案。诱导膜技术,牵张成骨,等等,已经被描述;然而,所涉及的长时间和高成本为新方案的研究开辟了新的前景。最近推出的“钻石概念”不仅基于改进的生物力学,而且还引入了生物刺激作为治疗的支柱。我们报告一例16岁的女性患者在交通事故后发生股骨干骨折,最初采用髓中心阻断钉治疗,进展为假性关节,表现为5厘米的骨质流失。治疗包括去除髓中心阻塞的钉子,切除不能存活的骨段,用另一根髓中心阻塞的钉子进行骨融合术,放置7厘米长的骨干异体移植物、富血小板血浆(PRP)、基质异体移植物和骨芯片,从而实现影像学和临床巩固;考虑到PRP是本病例中主要的骨科因素,在更短的时间内恢复肢体功能。
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