The physiological role of atrial natriuretic factor.

Abstract

The physiological role of atrial natriuretic factor in the regulation of cardiovascular homeostasis has not yet been defined. The principal mechanisms that control biosynthesis, secretion and clearance of the peptide, however, are well characterized. In addition, several biological functions of the peptide, originally identified by studying the results of exogenous administration, have been confirmed in humans and in experimental animals at physiological blood levels, as well as with the help of pharmacological tools such as clearance inhibitors and monoclonal antibodies. This article reviews the principal biological actions of atrial natriuretic factor in the context of their physiological significance.