SERUM LEVELS OF SELECT MICRONUTRIENTS IN PRIMIGRAVIDA WITH PREECLAMPSIA VERSUS THEIR NORMOTENSIVE COUNTERPARTS: A CASE CONTROL STUDY AT A TERTIARY TEACHING HOSPITAL IN KENYA.

Pulei An, Kinuthia J
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Abstract

Background: Preeclampsia (PE) is a one of the leading causes of maternal mortality as well as morbidity and long-term disability to mothers and newborns in sub-Saharan Africa. Various micronutrients have been implicated in its pathophysiology. Supplementation of some of these micronutrients, like calcium being recommended as part of the preventive strategies of PE in resource-poor countries. The status of these micronutrients and their relationship with PE vary from population to population. Objective: To investigate the serum levels of select micronutrients (Vitamin D, calcium, zinc, and selenium) in preeclamptic and normotensive primigravid women in a tertiary teaching hospital in Kenya. Methods: This was a case-control study. Primigravid controls matched for age and gestation with those with preeclampsia were included in the study. Data on their demographic and obstetric, nutritional were obtained. They were interviewed on frequency of consumption of specific nutrient rich foods. Blood samples were obtained for serum analysis of Vitamin D, Calcium, Selenium and Zinc levels. Results: 108 participants were included. There were no significant differences in age, educational level and income level between the two study groups. Mean serum calcium and Vitamin D levels were significantly lower among the participants with preeclampsia. The mean serum vitamin D level amongst cases and controls was 20.8±10.2 ng/ml and 28.6±7.9 ng/ml respectively (p<0.001) while the serum calcium levels were 2.2±0.3mmol/l for the cases and 2.3±0.09mmol/l for the controls (p=0.024). There was no statistically significant association between serum levels of Selenium and Zinc with preeclampsia. Most of the controls consumed diets rich in calcium in comparison to the cases. The controls were more likely to consume fish, one of the dietary sources of Vitamin D, compared to the cases. There were no differences in consumption of foods rich in zinc and selenium. Conclusion: Pregnant women with preeclampsia have lower serum levels of calcium and vitamin D compared to their normotensive counterparts.
与血压正常的子痫前期患儿相比,子痫前期患儿血清中选定微量营养素水平:肯尼亚一家三级教学医院的病例对照研究。
背景:子痫前期(PE)是撒哈拉以南非洲地区孕产妇死亡、发病率和新生儿长期残疾的主要原因之一。多种微量营养素参与了其病理生理。在资源贫乏的国家,建议补充其中一些微量营养素,如钙,作为体育预防战略的一部分。这些微量营养素的状况及其与PE的关系因人群而异。目的:了解肯尼亚某三级教学医院子痫前期和血压正常的初孕妇女血清微量营养素(维生素D、钙、锌和硒)水平。方法:采用病例-对照研究。与年龄和妊娠期相匹配的子痫前期患者也被纳入研究。获得了人口、产科和营养方面的数据。他们被问及食用特定营养丰富食物的频率。采集血样,分析血清中维生素D、钙、硒和锌的含量。结果:纳入108例受试者。两组患者的年龄、受教育程度和收入水平均无显著差异。子痫前期患者的平均血清钙和维生素D水平明显较低。两组血清维生素D水平分别为20.8±10.2 ng/ml和28.6±7.9 ng/ml (p<0.001),血清钙水平分别为2.2±0.3mmol/l和2.3±0.09mmol/l (p=0.024)。血清硒和锌水平与子痫前期无统计学意义的关联。与对照组相比,大多数对照组的饮食中都含有丰富的钙。与对照组相比,对照组更有可能食用鱼类,这是维生素D的饮食来源之一。在食用富含锌和硒的食物方面没有差异。结论:与血压正常的孕妇相比,子痫前期孕妇的血清钙和维生素D水平较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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