MODIFICATION OF THE PFEFFER PANCREONECROSIS MODEL FOR ASSESSING PANCREATIC SECRETION IN THE ACUTE PERIOD OF DISEASE

Abstract

A preliminary experimental study: Measurement of exocrine pancreatic secretion was performed on Wistar rats after an induction of acute pancreatitis by ‘closed duodenal loop’ (CDL) method (total number of animals = 39). After 24 hrs duration of AP the CDL content was evacuated by syringe and tested for amylase level (IU/ml). A near normal output remained in most animals (1987,35 ± 558,26, n = 12); moderately decreased output was 264,67 ± 162,74 (n = 9), and cessation of the output in n = 3 (0,6 ± 0,3) (q < 0,01 for each group). So, in our series the exocrine pancreatic output was found diverging largely with a normal secretion prevailing. Further study is warranted for some conclusive results to obtain.