Overgrowth Syndrome and Multi-Stage Reconstruction of Hand and Feet Deformations

Abstract

A case of asymmetric overgrowth of feet, fingers and toes is presented and the performed diagnostic and multi-stage surgical reconstruction described. The condition in hands and feet was already present at birth. The hypertrophic growth advanced progressively, and histological investigation of the affected tissues revealed no pathology. The examination of inner organs, skin, subcutaneous tissue, nerves and vessels showed no deviations, the girl's karyotype was normal, 46 xx, no mosaicism was confirmed. In view of the new diagnostic criteria, this case cannot be assigned to any of the overgrowth syndromes. The most suitable classification would be in the group of Proteus-like syndrome. At this time only isolated hypertrophy of soft tissues and skeleton is present. According to the data from the literature, later development of anomalies is possible, so Proteus-like syndrome cannot be completely excluded.