Efecto antagonista del flumazenil sobre el isoflurano en la emersión de la anestesia general

Abstract

Introduction and Objectives: isoflurane, an inhalational general anesthetic widely used in medical practice, belonging to the group of volatile liquids to gether with desflurane and sevoflurane, with various properties including seda -tion, hypnosis and anesthesia of patients undergoing treatment. surgical acts. volatile inhalational anesthetics (halogenated) as mechanism of action, has the property of increasing inhibitory synaptic transmission at postsynaptic level by potentiating ion channels regulated by ligand activated by alpha-aminobutyric acid (GABA). Flumazenil is a benzodiazepine antagonist belonging to the group of imidazobenzodiazepine. it is currently known that there is no specific drug capable of antagonizing the effects of halogenates that allow the rapid and complete recovery of general anesthesia, for this reason this work focuses its efforts on demonstrating whether flumazenil has the ability to reverse the ac tions of the patient. isoflurane and allow an early restoration of the level of consciousness. materials and methods : The study to be performed is a clini cal type of longitudinal, prospective, unicentric and double blind. The sample will be formed by patients who are going to be subjected to a balanced general anesthesia. The sample will be divided into 2 large groups: group C (control) and group F (Flumazenil). At the end of the surgery, the mixture will be admi nistered according to the selected group in a random manner (Flumazenil 0.25 mg or 0.9% solution in a 20 cc syringe) and the time of extubation, recovery time of the level of consciousness, time of discharge UCPA and hemodynamic state (FC, TAM and SO 2 ). Results : The flumazenil group showed a significantly shorter time from injection to extubation than the placebo group (p = 0.007). Differences in terms of shorter times needed to achieve Aldrete of 9 points in