[Nutritional status and chronic renal insufficiency].

F Fiorini, E Patrone, A Castelluccio
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引用次数: 0

Abstract

The occurrence of malnutrition in patients with chronic renal failure has been well documented, mostly in patients undergoing regular dialysis: these patients often suffer from protein-calorie malnutrition, but more seldom there are disturbances to be due to deficit of 1,25 dihydroxyvitamin D3, folic acid, vitamin B6, iron, zinc and L-carnitine, mostly in patients who do not get adequate supplementation. There are several causes for protein-calorie malnutrition in chronic renal insufficiency. These include uremia per se, altered hormonal milieu, abnormal amino acid metabolism due to uremia or to loss of metabolically active renal tissue. Dialysis treatment improves some of these abnormalities, but introduces others. On the other hand, it is well established that morbidity and mortality in chronic renal failure are influenced by their nutritional status: therefore it is important to know the factors and the mechanisms that cause malnutrition for its prevention, recognition and correction.

[营养状况与慢性肾功能不全]。
慢性肾衰竭患者营养不良的发生已有充分的文献记录,主要发生在定期透析的患者中:这些患者通常患有蛋白质-热量营养不良,但更罕见的是由于缺乏1,25二羟基维生素D3、叶酸、维生素B6、铁、锌和左旋肉碱而引起的紊乱,主要发生在补充不足的患者中。慢性肾功能不全导致蛋白质-热量营养不良的原因有很多。这些包括尿毒症本身、激素环境改变、尿毒症引起的氨基酸代谢异常或代谢活性肾组织的丧失。透析治疗可以改善这些异常,但也会引入其他异常。另一方面,慢性肾衰竭的发病率和死亡率受营养状况的影响,因此了解导致营养不良的因素和机制对于预防、识别和纠正营养不良具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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