Squared Coherence Analysis Might Suggest Cerebral Autoregulation Post-Surgery Impairment in Patients Undergoing Surgical Aortic Valve Replacement

V. Bari, F. Gelpi, B. Cairo, Noemi Cornara, Beatrice De Maria, M. Ranucci, A. Porta
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引用次数: 1

Abstract

A squared coherence (K2) approach was applied to investigate cerebral autoregulation (CA) in 33 patients (age: 63±14 yrs; 27 males) undergoing surgical aortic valve replacement (SAVR) before surgery (PRE), after surgery (POST) and after a 3-month follow-up (POST3). K2 was assessed between mean arterial pressure and mean cerebral blood flow velocity in very low frequency (VLF, 0.02-0.07 Hz), low frequency (LF, 0.07-0.15 Hz) and high frequency (HF, 0.15-0.4 Hz) bands at rest in supine position (REST) and during active standing (STAND). The significance of K2 was tested individually via a surrogate approach. Results showed that K2 in HF band increased during POST compared to PRE at REST but this rise was more limited during STAND. Analysis of K2 suggests a possible impairment of CA after SAVR that might expose patients to a higher risk of developing post-surgery cerebrovascular adverse events.
平方相干分析可能提示主动脉瓣置换术患者术后脑自动调节功能受损
采用平方相干(K2)方法对33例患者(年龄:63±14岁;27名男性)接受手术主动脉瓣置换术(SAVR)术前(PRE),术后(POST)和3个月随访(POST3)。在仰卧位(rest)和活动站立(STAND)休息时,在甚低频(VLF, 0.02-0.07 Hz)、低频(LF, 0.07-0.15 Hz)和高频(HF, 0.15-0.4 Hz)波段测量平均动脉压和平均脑血流速度之间的K2。通过替代法分别检测K2的显著性。结果表明,在休息状态下,与PRE相比,POST期间HF频段的K2升高,但STAND期间这种升高更为有限。对K2的分析表明,SAVR后CA可能受损,这可能使患者面临更高的术后脑血管不良事件风险。
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