Biomolecules Loading and Mesoporous SBA-15 Pore Sizes

Abstract

The encapsulation and immobilization of biomolecules on solid materials, mesoporous SBA-15, have been studied. Highly ordered hexagonal mesoporous silicates (MPS) with different mean pore sizes have been synthesized using two kinds of triblock copolymers (P123 or L123) as a template. The mixture of tetraethyl orthosilicate (TEOS) and the triblock copolymer (poly(ethylene glycol)poly(propylene glycol)-poly(ethylene glycol)) was stirred and hydrothermally treated at various temperatures to form the MPS structure. Higher temperatures during stirring and hydtrothermal treatment led to the enlargement of pore size. UV-spectrometry was performed to determine the amount of bovine serum albumin (BSA) encapsulated in MPS. It was found that the adsorption processes of BSA on/in MPS could be well described by intraparticle diffusion model.