The Effect of Active Vitamin D on Diabetic Nephropathy A Meta-Analysis of Randomized Controlled Trials

Abstract

Objective: The system evaluation of clinical curative effect of different concentration active vitamin D for diabetic nephropathy. Methods: We searched the Chinese VIP, Wan Fang Data, China National Knowledge Infrastructure, PubMed, Embase, and Google Scholar databases for relevant studies and extracted all eligible data. RevMan5.3 software was used for statistical analysis. Result: 20 randomized controlled trials (n=1450) met our criteria and were used for data extraction. The treatment groups have 856 cases and the control groups have 594 cases. The results of statistical analysis show that compared with the group of using ACEI/ARB simply, the combination of ACEI/ARB and different doses active vitamin d (0.25ug/d, 0.50ug/d, 0.25-0.5ug/d)can significantly reduce the 24-hour urinary protein (0.46%, P<0.00001) and (0.22%, P < 0.00001), and can decrease the hypersensitive C-reactive protein (0.63%, P=0.001) and (0.6%, P < 0.00001).However, there was no obvious difference in glycosylated hemoglobin and glomerular filtration rate, lower serum creatinine, increase calcium ion concentration. Conclusion: Meta-analysis showed that compared with the group of using ACEI/ARB simply, the impact of active vitamin D on diabetic nephropathy obviously, Especially 24-hour urine protein and hypersensitivity C-reactive protein. more randomized controlled trials are needed to be confirmed.