Thalamic theta field potentials and EEG: high thalamocortical coherence in patients with neurogenic pain, epilepsy and movement disorders

J Sarnthein, A Morel, A von Stein , D Jeanmonod
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引用次数: 77

Abstract

We simultaneously recorded local field potentials (LFP) in the thalamus and EEG on the scalp of 17 patients suffering from neurogenic pain, epilepsy and movement disorders. The EEG of 11 patients displayed enhanced power in the theta frequency range (4–8 Hz). The thalamic LFP of 14 patients peaked in the theta range. The theta coherence between EEG and LFP was significant for 12 patients and reached strengths up to 70%. These findings suggest that enhanced theta rhythmicity occurs in tight functional thalamocortical loops and is a major element in all three diseases investigated.

To investigate second-order phase-coupling between LFP frequency components, we computed the bicoherence and averaged over the group of patients. We found peaks in the theta band and the beta band (14–30 Hz), indicating phase correlations of oscillatory events in these frequency ranges with their first harmonic. A further peak indicates that phase coupling occurred also between theta and beta frequencies. This indicates a strong functional interaction between the generators of these oscillations. We also computed the cross-correlation between LFP spectral power at different frequencies. Although this measure is independent of phase, we found good agreement with the bicoherence patterns, pointing again to strong interaction between theta and beta rhythmicity. The overproduction of theta rhythms, the thalamocortical coherence and the correlation of theta with beta rhythms are key elements for the understanding of thalamocortical dysrhythmia (TCD).

丘脑θ波场电位和脑电图:神经性疼痛、癫痫和运动障碍患者的高丘脑皮质一致性
对17例神经性疼痛、癫痫和运动障碍患者的丘脑局部场电位(LFP)和头皮脑电图进行同步记录。11例患者的脑电图在θ频率范围(4-8 Hz)表现为功率增强。14例患者丘脑LFP在θ范围内达到峰值。12例患者脑电图与LFP之间的θ相干性显著,强度高达70%。这些发现表明,增强的θ波节律性发生在紧密的功能性丘脑皮质环中,并且是所研究的所有三种疾病的主要因素。为了研究LFP频率分量之间的二阶相位耦合,我们计算了双相干性并对患者组进行了平均。我们在θ波段和β波段(14-30 Hz)发现了峰值,表明这些频率范围内振荡事件与它们的一次谐波的相位相关性。进一步的峰值表明在θ和β频率之间也发生了相位耦合。这表明这些振荡的发生器之间有很强的功能相互作用。我们还计算了不同频率下LFP谱功率之间的相互关系。虽然这个测量是独立于相位的,但我们发现了与双相干模式的良好一致性,再次指出了θ和β节律之间的强相互作用。θ节律的过度产生、丘脑皮质的相干性以及θ与β节律的相关性是理解丘脑皮质节律异常(TCD)的关键因素。
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