Mini Review on Synthesis of Pyrimidinthione, Pyrimidinedione Derivatives and Their Biological Activity

Abstract

Over the past decade the evolution of organisms resistant to nearly all the class of antimicrobial agents has become a severe public health concern [1,2]. Heterocyclic compounds have received considerable attention owing to their synthetic and biological importance in the enhancement of the quality of human life. Among numerous heterocycles compounds that have been synthesized and evaluated for their pharmacological activities, chalcone, pyrimidinone and pyrimidinethione have played a crucial role in medicinal chemistry. It was demonstrated that the presence of reactive α, β-unsaturated keto function in chalcones was responsible for their antibacterial and antifungal activities [3].