Effect of Aerobic Exercise on Serum Adiponectin and Serum Malondialdehyde (MDA) In Type 1 Diabetic Patients

Abstract

Type 1 diabetes is fatal unless treated with insulin. Exercise interventions have been shown to be as efficient as the pharmaceutical agents to improve glycaemic control. The aim of the current study was to determine the effect of aerobic exercise on possible mechanisms controlling insulin resistance. Forty diabetic type 1 patients of both sexes (20 females and 20 males) were participated in the study. They were randomly divided into two equal groups. Study group comprised of 20 patients participated in a supervised moderate-intensity aerobic exercise program performed on bicycle ergometer for 50 minutes, 3 times per week, for 8 weeks, in addition to their medical treatment while the control group received only their medical treatment. The result showed that a significant decrease in insulin resistance in the Study group as compared to the control group. The mean values of adiponectin were significantly increased from 5.85±0.65 to 6.6±0.56 in the study group. The mean values of Malondialdehyde (MDA) and fasting glucose were significantly decreased from 7.2±0.98, 146.88±11.42 to 6.45±0.95, 133.87±11.99 respectively in the study group. It can be concluded that aerobic exercise has a positive effect on decreasing insulin resistance and hence decrease the incidence of diabetic complications.