THE EFFECTS OF HYDRO ALCOHOLIC EXTRACT OF MATRICARIA CHAMOMILLA FLOWER ON TESTOSTERONE AND GONADOTROPINS HORMONE IN ADULT MALE RAT

Journal of Jahrom University of Medical Sciences Pub Date : 2014-10-15 DOI:10.29252/JMJ.12.4.6

H. Johari, M. Khavarian, M. Moghtari, M. Kamali, H. Jahromi

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引用次数: 6

Abstract

Introduction: Chamomilla is a valuable plant that has been used in traditional medicine for thousands of years to treat different diseases. This study aimed to investigate the effects of chamomilla flower extract on pituitary-gonadal axis in adult male rats. Materials and Methods: In this experimental study, 45 adult male Wistar rats with a mean weight of 250-300 g were divided into five groups: control group, sham group and experimental groups 1, 2 and 3. The experimental groups, respectively received 10, 20 and 40 milligram per kilogram body weight of intraperitoneal injection of chamomile flower extract for 14 consecutive days. At the end of the treatment course, the rats were anesthetized with ether and their ventricular blood samples were collected for measuring serum concentration of gonadotropins and testosterone by radioimmunoassay. Data were analyzed using ANOVA. Results : The serum concentration of testosterone showed a significant decrease in experimental groups as compared with the sham group (p≤0.05). Nonetheless, the serum concentration of gonadotropins no showed a significant difference in experimental groups as compared with that of the control group. Conclusion: Given the results of this study, intraperitoneal injection of chamomile flower extract reduces testosterone secretion in male rats.

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洋甘菊水醇提取物对成年雄性大鼠睾酮和促性腺激素的影响

简介:洋甘菊是一种珍贵的植物，几千年来一直被用于传统医学中治疗不同的疾病。本研究旨在探讨洋甘菊提取物对成年雄性大鼠垂体-性腺轴的影响。材料与方法:将45只平均体重250 ~ 300 g的成年雄性Wistar大鼠分为5组:对照组、假手术组和实验组1、2、3。试验组分别按每公斤体重10、20、40毫克腹腔注射洋甘菊提取物，连续14 d。疗程结束后，采用乙醚麻醉大鼠，取脑室血，用放射免疫法测定血清促性腺激素和睾酮浓度。数据分析采用方差分析。结果:实验组大鼠血清睾酮浓度较假手术组明显降低(p≤0.05)。但试验组血清促性腺激素浓度与对照组相比差异有统计学意义。结论:根据本研究结果，腹腔注射洋甘菊提取物可降低雄性大鼠睾酮分泌。

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Journal of Jahrom University of Medical Sciences

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