On pharmacokinetic evaluation of model drugs distribution into rat central lymph.

Abstract

Numerous experimental data obtained in the studies of factors influencing the transfer of model drugs (diazepam, inulin, hippurate) into the lymphatic system were evaluated using compartmental pharmacokinetic analysis. The selection of kinetic equations for lymphatic data analysis in respect to blood ones is specific. Lymphatic kinetic equations correspond in every case tested with those used generally in blood kinetic analysis of drugs administered perorally. The lag time parameter is useful in this lymphatic analysis, too.