A Computational approach of phytochemicals from Bacopa monnieri in contrast to DPP-4 and peroxisome proliferator-activated receptors gamma as a Target for type-1 diabetes

Abstract

Affecting the vast majority of the population, diabetes has become one of the major causes of death in India and the world. With the growing number of diabetic people in India, one in six people in the world with diabetes is from India. Bacopa monnieri is a wonder herb having many pharmacological applicaions. Traditionally, Brahmi is used to improve memory and concentration. Asthma, bronchitis, gastric ulcers, irritable bowel syndrome, anxiety, etc. DDP-4 inhibitors cause antihyperglycemic effect and regulates blood glucose. PPARs effectively regulates blood glucose levels and reduce triglycerides. The isoform of PPARs i.e., PPARγ plays a vital role in insulin sensitivity. The role of these protein receptors in treating T1DM is under research. Though few instances prove their effectiveness to treat T1DM, its efficacy is questionable and requires more research input. Branched chain and aromatic amino acids like tyrosine and glutamine have their functional role in regulating blood glucose level and onset of diabetic conditions. Bioactive ligands like Jujubogenin, bacogenin and luteolin are selected based on their interactions and binding affinity. T1DM mainly affects children and prediabetic period before the onset of T1DM provides us the golden opportunity to treat or suppress the condition through medical interventions. Thus, the ligand-macromolecule interaction and their efficacy in controlling Type-1 diabetes mellitus is the basis of this study.