A Deconstructed Replication of a Time of Test Study Using the AGIS Metric

S. Counsell, S. Swift, A. Tucker
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引用次数: 1

Abstract

In medical practice, glaucoma severity is usually measured using the Advanced Glaucoma Intervention Studies (AGIS) metric. In a previous study [2], we replicated the work of Montolio et al., [5] and demonstrated that, for a larger dataset, time of day of test using the AGIS metric did make a difference to the measurement of glaucoma, supporting Montolio et als work. However, in our earlier study, we used the AGIS scores for both eyes combined. In this paper, we use the measurement from just one eye at a time. A dataset of 14389 left eye AGIS scores and the same number for the right eye from 2468 Moorfield Eye Hospital patients was used as the empirical basis. We then re-compared time of test results with those of Montolios study. Results revealed that using the values from just one eye (as opposed to both) may give a distorted picture of the AGIS scores; differences in the same time period were found between the two eyes. This may have implications for choice of sampling data and analysis of glaucoma using the AGIS metric.
使用AGIS度量对测试时间研究的解构复制
在医学实践中,青光眼的严重程度通常使用高级青光眼干预研究(AGIS)指标来测量。在之前的研究[2]中,我们重复了Montolio等人的工作[5],并证明,对于更大的数据集,使用AGIS度量的测试时间确实对青光眼的测量有影响,支持Montolio等人的工作。然而,在我们早期的研究中,我们使用了两只眼睛的AGIS评分。在本文中,我们每次只使用一只眼睛的测量。采用2468名Moorfield眼科医院患者的14389份左眼AGIS评分和相同数量的右眼AGIS评分数据集作为实证基础。然后,我们将测试结果与Montolios研究的时间进行了重新比较。结果显示,只使用一只眼睛(而不是两只眼睛)的值可能会扭曲AGIS分数的图像;在同一时期,两只眼睛之间也发现了差异。这可能对选择采样数据和使用AGIS指标分析青光眼有影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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