CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF NEUROLOGICAL VARIANTS OF POST-COVID SYNDROME ON THE EXAMPLE OF THE NEUROLOGICAL CLINIC OF THE STATE NOVOSIBIRSK REGIONAL CLINICAL HOSPITAL

Abstract

Introduction. On March 11, 2020, WHO declared a pandemic of a new coronavirus infection. In addition to the pandemic's high mortality worldwide, its deferred effects are receiving increasing attention. With the accumulation of research data, it became obvious that a new coronavirus infection is capable of inducing both direct and indirect effects on the nervous system. Aim. The study of the clinical and epidemiological characteristics of neurological variants of post-covid syndrome using the example of the neurological clinic of the State Budgetary Healthcare Institution Novosibirsk Regional Clinical Hospital for the period from July 2020 to February 2022. Materials and methods. A retrospective analysis of 1 500 case histories of patients with a past history of COVID-19 admitted with a manifestation of various neurological diseases for the period from July 2020 to January 2022. In addition to the manifestation of neurological diseases , we took into consideration gender, age, concomitant diseases, and duration of a new coronavirus infection. Results. Of the analyzed case histories with laboratory-confirmed COVID-19 and overt neurological conditions, 30 people were identified. Concomitant neurological disorders with a predominant lesion of the peripheral nervous system accounted for 23% (according to the type of Guillain-Barré syndrome — 16%, the remaining 7% had symptoms of chronic demyelinating polyneuropathy), the central nervous system — 74% (isolated cases of meningoencephalitis, autoimmune encephalomyelitis, ischemic stroke; up to 60% of encephalopathies of various origins), 3% accounted for musculoskeletal pathology, represented by idiopathic myodystrophy. Conclusion. Thus, no significant differences were found between the results obtained and the data of foreign and domestic colleagues. The precise data on frequency of neurological variants of post-COVID syndrome are currently unknown, however, there is a tendency that patients who have had a severe form of COVID-19 are more prone to the development of neurological complications after infection in the period up to 6 months.