Effectiveness of Atenolol on the Basis of Pattern of Side Effects in Hypertensive Patients

Maria Fareed Siddiqui, Mehreen Rasheed, Ahmad Alwazzan, S. Sarwar
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Abstract

Hypertension plays a significant role in changing Insulin parameter. They are taken as valid diagnostic markers in determining side effects of anti-hypertensive drugs. These parameters are grossly affected by the use of beta blockers which are used to control hypertension. Objective: To determine the effects of atenolol, a beta blocker on insulin when taking alone in hypertensive patients. Methods: A total of 80 patients participated in this study of which 43 patients were taking atenolol alone while 37 were taking atenolol in combination with other anti-hypertensive drugs and 20 healthy controls were included of all age groups population to make a comparison and to find variation in values of insulin levels, in patients experiencing hypertension. Medical efficacy was evaluated on the basis of variations in insulin levels upon use of anti-hypertensive medications. ELISA technique was used for conducting insulin levels. Results: We found significant results of insulin values because atenolol cause hyperglycemia Atenolol was non-significant in both groups of patients having low insulin levels due to use of atenolol alone or use of atenolol in combination therapy. Other anti-hypertensive drugs did not affect the insulin levels therefore variation is basically because of atenolol so the main focus of our study was atenolol. Conclusions: Atenolol prove efficacy but it also causes the disturbance in insulin levels therefore we recommend use of any other drug in conjunction with atenolol to avoid insulin variation due to atenolol. Further these results may be employed on large patient population for strengthening our evidences.  
阿替洛尔对高血压患者不良反应模式的疗效观察
高血压对胰岛素参数的改变有重要作用。它们可作为判定抗高血压药物副作用的有效诊断指标。这些参数受到用于控制高血压的-受体阻滞剂使用的严重影响。目的:探讨高血压患者单独服用β受体阻滞剂阿替洛尔对胰岛素的影响。方法:选取80例高血压患者,其中单独服用阿替洛尔43例,联合其他降压药37例,并在各年龄组人群中选取健康对照20例,比较高血压患者胰岛素水平的变化情况。根据使用降压药物后胰岛素水平的变化来评估药物疗效。ELISA法测定胰岛素水平。结果:我们发现胰岛素值的显著结果,因为阿替洛尔引起高血糖,阿替洛尔在两组由于单独使用阿替洛尔或联合使用阿替洛尔而胰岛素水平较低的患者中不显著。其他降压药不影响胰岛素水平因此变化主要是因为阿替洛尔所以我们研究的重点是阿替洛尔。结论:阿替洛尔证明有效,但它也会引起胰岛素水平的紊乱,因此我们建议使用任何其他药物与阿替洛尔联合使用,以避免因阿替洛尔引起的胰岛素变化。此外,这些结果可用于大患者群体,以加强我们的证据。
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