[Determination of parasite-specific antibodies during human schistosomiasis--diagnostic relevance].

Abstract

Sera from patients with schistosomiasis (Schistosoma mansoni or S. haematobium) were examined for the presence of parasite specific antibodies (total antibodies), specific IgE and IgG4 antibodies by means fo ELISA technique using antigens prepared from adult worms of S. mansoni. Individuals from tropical countries who had no schistosomiasis and blood donors from Germany were studied for comparison. Significantly higher levels of specific antibodies were given by sera from patients with schistosomiasis than by controls in the tests for total antibodies, IgE and IgG4. The use of these results in diagnosis is compared and assessed with microscopic-parasitological methods.