D Droumev, D Pashov, M Droumev, S Vangelov, E Velikova, I Kanelov, L Lashev, R Moutafchieva
{"title":"Slow release bolus for small ruminants: in vitro release of tetracycline compared with serum concentrations of the antibiotic in sheep.","authors":"D Droumev, D Pashov, M Droumev, S Vangelov, E Velikova, I Kanelov, L Lashev, R Moutafchieva","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Two formulations of slow release boluses for small ruminants containing tetracycline hydrochloride in a compressed form were investigated in vitro and in vivo in adult sheep. An in vitro dissolution test was used for the preliminary selection of the 2 boluses. It was shown that the non-cumulative kinetics of tetracycline release in vitro were predictive of the tetracycline serum levels in sheep treated orally with the 2 boluses. The maximum concentrations revealed by the in vitro and in vivo curves were obtained at almost the same Tmax and, in vivo, the therapeutic serum levels were maintained for about 5 days. It is concluded that an in vitro approach is of value in predicting the kinetic profiles of a long-acting tetracycline bolus in sheep.</p>","PeriodicalId":7914,"journal":{"name":"Annales de recherches veterinaires. Annals of veterinary research","volume":"23 3","pages":"215-23"},"PeriodicalIF":0.0000,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annales de recherches veterinaires. Annals of veterinary research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Two formulations of slow release boluses for small ruminants containing tetracycline hydrochloride in a compressed form were investigated in vitro and in vivo in adult sheep. An in vitro dissolution test was used for the preliminary selection of the 2 boluses. It was shown that the non-cumulative kinetics of tetracycline release in vitro were predictive of the tetracycline serum levels in sheep treated orally with the 2 boluses. The maximum concentrations revealed by the in vitro and in vivo curves were obtained at almost the same Tmax and, in vivo, the therapeutic serum levels were maintained for about 5 days. It is concluded that an in vitro approach is of value in predicting the kinetic profiles of a long-acting tetracycline bolus in sheep.