Slow release bolus for small ruminants: in vitro release of tetracycline compared with serum concentrations of the antibiotic in sheep.

D Droumev, D Pashov, M Droumev, S Vangelov, E Velikova, I Kanelov, L Lashev, R Moutafchieva
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Abstract

Two formulations of slow release boluses for small ruminants containing tetracycline hydrochloride in a compressed form were investigated in vitro and in vivo in adult sheep. An in vitro dissolution test was used for the preliminary selection of the 2 boluses. It was shown that the non-cumulative kinetics of tetracycline release in vitro were predictive of the tetracycline serum levels in sheep treated orally with the 2 boluses. The maximum concentrations revealed by the in vitro and in vivo curves were obtained at almost the same Tmax and, in vivo, the therapeutic serum levels were maintained for about 5 days. It is concluded that an in vitro approach is of value in predicting the kinetic profiles of a long-acting tetracycline bolus in sheep.

小反刍动物缓释丸:四环素体外释放与绵羊血清浓度的比较。
研究了两种含盐酸四环素压缩制剂的小反刍动物缓释丸的体外和体内实验。采用体外溶出度试验对2个小丸进行初步筛选。结果表明,体外四环素释放的非累积动力学可预测口服2丸四环素的绵羊血清水平。体外和体内曲线显示的最大浓度在几乎相同的Tmax下获得,体内治疗血清水平维持约5天。由此得出结论,体外实验方法对预测长效四环素丸在羊体内的动力学分布具有一定的价值。
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