Simulation analysis of coupling characteristics between cardiac myocyte and MEAs

Abstract

The electrophysiological properties of excitable cells can reflect the state of cells. However, the action potentials (APs) are weak and difficult to detect. The influencing factors of AP measurement are studied by analyzing the equivalent circuit model between cardiac myocyte and microelectrode. After simulation experiments, the improved methods of the parameters that greatly influence on the signal measurement were adopted, and the dialectical relationship among the parameters was analyzed. Aiming at the problem of low signal resolution in planar microelectrodes array, the adjusted methods of electrode parameters were proposed. The experimental results show that the proposed method can change some parameter serious influencing on signal measurement, and is useful to obtain the state between APs and cell more accurately.